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妊娠期糖尿病与随后的长期死亡风险的关联
Yi-Xin Wang1,2, Makiko Mitsunami2, JoAnn E Manson3,4,5
1Department of Environmental Health, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
孕期糖尿病女性面临的长期死亡风险略有增加,尤其是心血管疾病. 这突显了监测有妊娠糖尿病史的妇女慢性健康状况的重要性.
科学领域:
- 生殖健康 生殖健康
- 流行病学 流行病学
- 慢性疾病流行病学 慢性疾病流行病学
背景情况:
- 孕期糖尿病 (GDM) 与各种慢性疾病有关.
- 关于GDM与长期死亡率之间的联系的研究有限.
- 了解这种联系对于长期的女性健康管理至关重要.
研究的目的:
- 调查GDM与长期总死亡风险之间的关联.
- 检查GDM与特定原因死亡风险之间的关联.
- 为了确定可能改变GDM-死亡率关联的风险因素.
主要方法:
- 一项前性队列研究,利用护士健康研究II (1989-2019) 的数据.
- 纳入了91,426名参与者,追踪了超过260万人年.
- 考克斯比例危险回归模型被用于估计死亡危险比率 (HRs).
主要成果:
- 病史上的GDM与28%的总死亡风险增加有关 (HR,1.28;95% CI,1.13-1.44).
- GDM与59%的心血管疾病死亡风险增加有关 (HR,1.59;95% CI,1.03-2.47).
- 即使调整了混因素后,这种关联仍然很重要,并且无论2型糖尿病的发展如何,都会持续存在.
结论:
- 孕期糖尿病与长期死亡风险小但较高有关.
- GDM是随后的心血管疾病死亡率的重要风险因素.
- 这些发现强调了长期健康监测对有GDM病史的妇女的重要性.
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