产前暴露于寨卡病毒与青少年 rhesus macaques 的侧面生殖细胞核异常有关
Erin E Ball1,2,3, Jeffrey L Bennett4,5, Rebekah I Keesler4,6
1Department of Pathology, Microbiology and Immunology, University of California, Davis, California.
Neuroreport
|September 11, 2023
概括
产前Zika病毒 (ZIKV) 暴露会对侧面生殖细胞核 (LGN) 造成持久损伤,这是一个关键的视觉处理中心. 这项研究证实ZIKV诱导的LGN病理从胎儿发育到童年持续存在.
科学领域:
- 神经科学是一个神经科学.
- 病毒学 病毒学
- 发展生物学 发展生物学
背景情况:
- 众所周知,寨卡病毒 (ZIKV) 引起神经病理,特别是在发育中的胎儿中,影响眼睛和视觉通路.
- 以前的研究表明,胎儿 rhesus 子中ZIKV 暴露导致侧侧生殖核 (LGN) 的异常.
研究的目的:
- 在产前 rhesus子模型中复制ZIKV诱导的LGN病理的发现.
- 为了确定与ZIKV相关的LGN异常是否在整个儿童发育过程中持续存在.
主要方法:
- 两只幼年 rhesus 子在产前暴露于 ZIKV 和两个年龄相匹配的对照组的 LGNs 的组织学分析.
- 定量神经解剖学分析侧重于LGN的大小,结构和层次组织.
- 在怀孕的 rhesus 子中,ZIKV 感染是通过静脉注射和胚胎内注射途径实现的.
主要成果:
- 产前ZIKV暴露导致LGN的显著发育异常.
- 观察到的异常包括不组织,层混合,层状不连续性和LGN内的细胞密度降低.
- 这些病理变化在对照动物中没有出现.
结论:
- 早期胎儿暴露于ZIKV会导致大脑视觉通路的持续发育异常,特别是LGN.
- 在暴露于ZIKV的胎儿中观察到的LGN病理持续到童年,突出显示了长期的神经后果.
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