在被诊断为前性痴呆症的个体中,临床表现的种族差异
Hannah A Jin1, Corey T McMillan1, Isabel Yannatos1
1Penn Frontotemporal Degeneration Center, Department of Neurology, School of Medicine, University of Pennsylvania, Philadelphia.
JAMA neurology
|September 11, 2023
概括
在前性痴呆症 (FTD) 呈现方面存在种族差异. 黑人个体表现出更大的严重性和损伤,而亚裔个体比白人个体有更多的冷漠和行为症状.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 精神病学是一个精神病学.
背景情况:
- 之前的研究表明,痴呆症呈现的种族差异.
- 这些差异尚未在前性痴呆症 (FTD) 中得到具体研究.
研究的目的:
- 在被诊断为FTD的个体中探索痴呆症严重程度,功能障碍和神经精神症状的种族差异.
- 为了比较有FTD的亚洲人,黑人和白人.
主要方法:
- 一项探索性横截面研究使用国家阿尔茨海默氏症协调中心 (NACC) 从2005年6月到2021年8月的数据.
- 评估亚洲,黑人和白人的FTD (行为变体FTD或初级渐进性失语症).
- 使用回归模型检查了FTLD-CDR,功能评估量表和神经精神病 inventory 的种族差异,并将其匹配以解决群体失衡问题.
主要成果:
- 样本包括2478个人:59个亚洲人 (2.4%),63个黑人 (2.5%),2356个白人 (95.1%).
- 与白人相比,黑人个体表现出更高的痴呆症严重程度 (FTLD-CDR,FTLD-CDR框的总和) 和更大的功能障碍.
- 与白人相比,亚洲人表现出更高的冷漠,夜间行为和食欲/饮食变化的频率. 黑人有更高的妄想,兴奋和抑郁的比率.
结论:
- 这项研究表明FTD表现的种族差异很大,包括严重程度,功能障碍和神经精神症状.
- 未来的研究应该解决这些差异的决定因素,并改善少数群体在痴呆症登记册中的代表性.
- 这些发现强调了FTD诊断和护理中需要文化敏感的方法.
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