内微生物群调节上皮层癌症对米托坦的反应
Giulia Cantini1,2,3,4, Elena Niccolai5, Letizia Canu1,2,3
1Department of Experimental and Clinical Biomedical Sciences, Endocrinology Section, University of Florence, Florence, Italy.
Endocrine-related cancer
|September 11, 2023
概括
该研究发现,特定的细菌,特别是蛋白质细菌,存在于上腺皮质癌 (ACC) 瘤中,并影响治疗结果. 某些细菌的较高丰度与患者中较好的线粒 (MTT) 水平相关.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 微生物学 微生物学
背景情况:
- 瘤微环境包括透的微生物群,这可能会影响癌症的进展和治疗反应.
- 皮上腺癌 (ACC) 是一种具有有限治疗效率的侵袭性内分泌恶性瘤.
- 在ACC中需要用于米托坦 (MTT) 治疗的预测标志物,以优化患者管理.
研究的目的:
- 在ACC组织中调查内细菌微生物群DNA的存在和组成.
- 探索细菌形状,瘤特征和米托 (MTT) 水平之间的关联.
- 确定潜在的微生物生物标志物,以预测ACC患者的MTT治疗反应.
主要方法:
- 在26个人类ACC组织和9个健康的上腺样本中分析细菌DNA.
- 瘤和健康组织之间的微生物组成的比较.
- 细菌丰富度,瘤大小,Ki67,皮质醇分泌和循环MTT水平之间的相关性分析.
主要成果:
- 在所有上腺样本中检测到细菌DNA,在ACC和健康组织之间存在显著的组成差异.
- 在ACC组织中,蛋白质细菌 (Pseudomonas,Serratia) 的数量较高.
- 低蛋白质细菌丰富度与较小的瘤大小,较低的Ki67和减少的皮质醇分泌相关.
- 较高的蛋白质细菌, Pseudomonas 和 Serratia 丰度与9个月的 MTT 水平增加有关.
结论:
- 人类的ACC藏着透的细菌,代表了瘤微环境的新方面.
- 特定的细菌特征,特别是蛋白质细菌的丰富性,与瘤特征和患者对米托 (MTT) 治疗的反应有关.
- 内微生物群可能会影响米托坦 (MTT) 的药理动力学,这表明它有可能作为预测生物标志物.
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