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Updated: Jul 16, 2025

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
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应用一个进化不匹配框架来理解疾病易感性.

Amanda J Lea1, Andrew G Clark2, Andrew W Dahl3

  • 1Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, United States of America.

PLoS biology
|September 11, 2023
PubMed
概括

进化不匹配假设解释了肥胖和糖尿病等非传染性疾病 (NCD) 的增加. 在经历快速生活方式变化的人群中研究遗传易感性可以识别引起疾病的基因环境相互作用.

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