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享乐饮食,肥胖和成是由于人类大脑进化过程中,Y型神经在脑内核中增加的结果
Mary Ann Raghanti1,2, Elaine N Miller3,4, Danielle N Jones1,2
1Department of Anthropology and School of Biomedical Sciences, Kent State University, Kent, OH 44242.
概括
人类大脑在核 (NAc) 中的神经Y (NPY) 比其他灵长类动物更多. 这可能解释了人类对成和饮食障碍的独特脆弱性.
科学领域:
- 神经科学是一个神经科学.
- 灵长类动物的比较解剖学
- 神经生物学 神经生物学 神经生物学
背景情况:
- 核聚集体 (NAc) 对于动机,奖励和行为至关重要.
- 神经Y (NPY) 在NAc中高度缩,影响奖励,情绪和物质使用.
- 以前的研究表明NPY在成和脂肪摄入中的作用.
研究的目的:
- 研究13种灵长类动物中NPY内化和NAc中神经元的差异.
- 确定NAc NPY变化是否与行为或生命史特征相关.
- 为了比较人类和其他类人灵长类动物之间的NPY概况.
主要方法:
- 在NAc中的NPY-免疫反应轴突和神经元的量化.
- 对13种灵长类动物进行比较分析,包括人类,大猿和子.
- 对大脑大小进行统计调整以评估NPY密度.
主要成果:
- 与其他灵长类相比,人类在NAc中表现出明显更密集的NPY内化,即使控制了大脑大小.
- 这种更密集的NPY内化是通过轴突长度密度相对于神经元密度来衡量的.
- 这些发现补充了先前的工作,显示了人类NAc中多巴胺基内尔化增加.
结论:
- 人类的NAc具有独特的神经化学特征,其特征是NPY增加和多巴胺内化.
- 这种独特的特征可能会使人类容易上,饮食障碍和肥胖.
- 这些结构性属性很可能在人类的早期发展,在认知专业化之前.
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