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从CaCO₃基的皮克林格乳液制备酸反应性抗泡

Rabia Zia¹, Albert T Poortinga², Akmal Nazir³

¹Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands.

Journal of colloid and interface science

|September 11, 2023

概括

碳酸 (CaCO3) 抗泡提供对酸反应的药物输送,在胃等酸性条件下释放封装药物. 这些CaCO3抗泡表现出高度的药物捕获和受控释放,与稳定的二氧化抗泡不同.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
制药科学制药科学

背景情况:

防气泡,稳定由水化烟二氧化,在中性和酸性介质中稳定.
开发对酸反应的抗泡对于有针对性的药物输送至关重要,特别是对于胃部应用.
碳酸 (CaCO3) 颗粒提供了酸降解抗泡的潜力.

研究的目的:

使用碳酸 (CaCO3) 颗粒开发和描述对酸反应的抗泡.
评估不同pH值的CaCO3稳定抗泡的药物释放特征.
为了比较CaCO3抗泡的性能与传统的基于的抗泡.

主要方法:

制备了两种类型的CaCO3稳定抗泡:一种是用酸涂层的CaCO3,另一种是用原生CaCO3和乙醇乳酸盐.
确定了一个模型药物 - - 甲蓝 (MB) 的捕获效率.
药物释放研究在pH 2 (模拟胃状况) 和中性pH进行.

主要成果:

稳定的CaCO3稳定抗泡成功生产,药物捕获效率约为85%.
在pH 2下,在几分钟内观察到甲蓝 (∼60%) 的快速释放,在30分钟内达到80%.
在中性pH值下,超过70%的药物至少在2小时内保持封装,这表明pH值依赖释放.

结论:

CaCO3颗粒,特别是当它们被酸预涂层时,可以形成适合药物输送的稳定抗泡.
在低pH值下CaCO3的酸触发降解导致抗泡破坏稳定和药物释放,使得有针对性的胃药物输送成为可能.
稳定CaCO3的抗气泡显示出控制和响应药物释放应用的巨大潜力.

关键词:

它们对酸有反应性.这是一种抗泡药.氧化 (CaCO(3) 是一种药物交付是药物交付的过程.皮克林乳液是一种皮克林乳液.

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Colloids

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