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Updated: Jul 16, 2025

Author Spotlight: Exploring the Frontier of mRNA Research with Poly A Tail Analysis Techniques
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Author Spotlight: Exploring the Frontier of mRNA Research with Poly A Tail Analysis Techniques

Published on: January 12, 2024

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一个单核酸分辨率毛细体凝电泳工作流程,用于在开发mRNA疗法和疫苗的过程中,对多分子A尾部的表征

Deanna Di Grandi1, Daniel M Dayeh1, Keerat Kaur2

  • 1Protein Biochemistry, Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591, USA.

Journal of pharmaceutical and biomedical analysis
|September 11, 2023
PubMed
概括

一种新的毛细管凝电泳方法准确地测量信使RNA (mRNA) 聚甲尾长. 该技术提供了一种合适的释放方法,用于监测mRNA疗法和疫苗中的关键质量属性.

关键词:
离子交换液体染色学 (AEX-LC) 是一种毛细管凝电泳 (CGE) 是一种在体外转录的信使RNA (IVT mRNA)离子对逆相液态色谱 (IPRP-LC) 是一种波利 (Poly) 尾巴 (A) 是一个多重的尾巴.单核酸分辨率是一个单核酸.

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