探索基于网络药理学和尿液蛋白质的HPV和BC的潜在点
Shun Wan1, Kun-Peng Li1, Chen-Yang Wang1
1Department of Urology, Lanzhou University Second Hospital, Lanzhou 730000, China; Gansu Province Clinical Research Center for Urology, Lanzhou 730000, China.
Journal of pharmaceutical and biomedical analysis
|September 11, 2023
概括
人类乳头瘤病毒 (HPV) 相关的膀癌 (BC) 影响了许多人. 阿斯特拉加利雷迪克斯 (AR) 通过奎尔塞丁向EGFR,显示HPV-BC患者的治疗潜力.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 人类乳头瘤病毒 (HPV) 感染是膀癌 (BC) 的重要原因,特别是在发展中国家.
- 目前的HPV疫苗对已有HPV感染的BC患者没有好处.
研究的目的:
- 为了确定与HPV相关的BC中的预后蛋白质特征.
- 为了研究阿斯特拉加利雷迪克斯 (AR) 对HPV-BC的治疗潜力.
主要方法:
- 转录学和差异基因查.
- 网络药理学用于AR组件和目标分析.
- 分子对接,虚拟模拟,尿蛋白学和RT-PCR.
主要成果:
- 确定了11个与HPV_BC相关的蛋白质特征,具有预后影响.
- EGFR,CTNNB1,MYC,MMP9,CXCR4,JUN和CXCL12的高表达与预后不佳相关.
- 来自AR的Quercetin显示了与EGFR的高亲和力结合,这是HPV-BC患者中确定的关键标.
结论:
- 阿斯特拉加利拉迪克斯 (AR) 通过其成分奎尔塞来向EGFR.
- 这种相互作用表明HPV相关的膀癌的潜在治疗策略.
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