COVID-19或SARS-COV-2疫苗对精子参数的影响:系统审查和元分析
Diogo Edele Santos1, Tamy Colonetti1, Maria Laura Rodrigues Uggioni1
1Laboratory of Translational Biomedicine, Universidade do Extremo Sul Catarinense, Av. Universitária, 1105, Universitário, CEP 88806-000 Criciúma, SC, Brazil.
Journal of reproductive immunology
|September 11, 2023
概括
这次审查发现COVID-19对精子参数产生了负面影响. 然而,mRNA疫苗对男性生殖没有显著的不良影响,这表明疫苗对生育的安全性.
科学领域:
- 生殖医学 生殖医学
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
背景情况:
- COVID-19大流行和随后的疫苗接种活动引起了人们对男性生殖健康潜在影响的担忧.
- 了解SARS-CoV-2感染和mRNA疫苗对精子参数的影响对于公共卫生和生育咨询至关重要.
研究的目的:
- 系统地审查和元分析有关SARS-CoV-2感染和mRNA疫苗对男性生殖参数影响的现有证据.
- 为了评估COVID-19和疫苗接种后的精子度,运动性和形态学的变化.
主要方法:
- 在主要数据库 (PubMed,BVS,Embase,Cochrane图书馆) 进行了全面的文献搜索.
- 包括观察性研究 (队列,病例控制,横截面),评估与COVID-19和mRNA疫苗相关的精子参数.
- 对来自选定的研究的数据进行了元分析,以量化影响.
主要成果:
- 分析表明,在COVID-19大流行之前和之后,精子度,渐进性运动性,总运动性和正常形态学存在显著的负面差异,尽管证据质量较低.
- 对mRNA疫苗 (256名男性) 五项研究的分析显示,精子总运动率没有显著差异,这表明缺乏有害影响.
- 对疫苗效应的证据质量被认为是低的.
结论:
- COVID-19 疫情本身似乎对某些男性精液参数产生了负面影响.
- 目前的低质量证据表明mRNA疫苗不会对男性生殖功能产生不利影响.
- 需要进一步进行高质量的研究,以确定SARS-CoV-2和疫苗对男性生育能力的长期影响.
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