产前压力对儿童肠道微生物群的长期和三个月特异性影响
Laura Rojas1, Marcel van de Wouw1, Yanan Wang2
1Department of Pediatrics, University of Calgary, Calgary, Alberta, Canada.
Psychoneuroendocrinology
|September 11, 2023
概括
母亲产前压力会影响孩子的肠道微生物群和代谢物,直到学龄前. 这些发现突出了支持儿童发展的干预措施的潜在目标.
科学领域:
- 微生物学 微生物学
- 发展心理学 发展心理学
- 人体生理学 人体生理学
背景情况:
- 产前压力很常见,与婴儿肠道微生物群的改变有关.
- 这些变化的持续到学前阶段,当肠道微生物群成熟时,尚不清楚.
研究的目的:
- 调查产前压力指标 (心理压力,压力生理学) 与儿童的肠道微生物群组成和3-4岁时的代谢物之间的关联.
主要方法:
- 在怀孕期间测量了母亲的心理压力 (焦虑,抑郁情绪) 和唾液皮质醇.
- 儿童肠道微生物群组成 (16S rRNA测序) 和便代谢组 (LC-MS/MS) 在3-4岁时被分析.
- 相关性和代谢分析被用来评估产前压力和儿童肠道微生物组/代谢组之间的关联.
主要成果:
- 怀孕期间母亲的抑郁情绪和焦虑与改变的肠道微生物多样性和儿童的特定细菌丰度相关.
- 产前皮质醇水平与肠道微生物多样性和便代谢组的变化有关.
- 在产前压力指标和细菌种群 (例如,Eggerthella,Ruminococcaceae) 和代谢途径之间发现了特定的关联.
结论:
- 产前心理压力和皮质醇水平与学龄前儿童的肠道微生物群组成和便代谢相关.
- 这些发现表明,肠道微生物组可能是通过产前压力影响儿童发育的途径.
- 了解这些联系可能有助于为暴露于产前压力的儿童开发针对微生物群的干预措施.
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