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含有反向菌根的自我乳化药物输送系统 (SEDDS):治疗性的先进口服配方

Arne Matteo Jörgensen¹, Christian Steinbring¹, Daniel Stengel¹

¹Department of Pharmaceutical Technology, University of Innsbruck, Institute of Pharmacy, Center for Chemistry and Biomedicine, Innrain 80-82, Innsbruck, 6020, Austria.

Advanced healthcare materials

|September 11, 2023

概括

自乳化药物递送系统 (SEDDS) 中的干逆 (dRMs) 提供了一种新的口服递送方法. 这种方法增强了类药物加载和细胞吸收,保持了抗菌活性.

科学领域:

制药科学制药科学
药物运输药物运输药物运输
纳米技术纳米技术

背景情况:

疏水性离子配对是一种用于将类药物纳入基于脂质的纳米载体的常见方法.
需要使用替代方法来改善SEDDS等口服递送系统的脂友复合体形成.

研究的目的:

开发和特征自乳化药物递送系统 (SEDDS) 结合干逆 (dRMs) 用于口服递送模型类药物聚米辛B (PMB).
评估与不同表面活性剂形成的dRM在增强PMB负载,释放动力学,细胞吸收和维持活性方面的效率.

主要方法:

使用阳离子 (AOT),阴离子 (DODAB),离子 (SL) 或非阳离子 (P85) 表面活性剂,开发含有聚米辛B (PMB) 的dRMs的SEDDS.
用颗粒大小,药物有效载荷,体外释放动力学,Caco-2细胞吸收和PMB的抗菌活性来表征SEDDS.

主要成果:

SEDDS-dRMs的尺寸从22.2到61.7纳米不等,有效载荷高达2%,明显高于疏水离子离子配对.
观察到DODAB和SL-SEDDS-dRMs的持续释放,而P85和AOT-SEDDS-dRMs在6小时内没有释放.
在DODAB-SEDDS-dRMs中,Caco-2细胞吸收率最高 (约100%在4小时内),其次是AOT-SEDDS-dRMs (约20%).
在所有测试的SEDDS-dRMs配方中,polymyxin B的抗菌活性被保留了.

结论:

结合干逆的SEDDS代表了口服类药物递送的有希望和潜在的变革性战略.
表面活性剂的选择显著影响SEDDS-dRMs配方的物理化学特性和生物性能.
与传统方法相比,这种新的方法提供了优越的载荷和增强的细胞吸收.

关键词:

药物释放释放药物释放药物释放的时间纳米载体的纳米载体提供口服的输送.增强有效载荷的增强聚氨基 B 聚氨基 B 是一种

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