Schistosoma mansoni诱导的氧化应激触发肝细胞增殖
Verena von Bülow1, Maryam Schneider1, Dorothee Dreizler1
1Department of Gastroenterology, Justus Liebig University Giessen, Giessen, Germany.
Cellular and molecular gastroenterology and hepatology
|September 11, 2023
概括
杆菌感染会通过氧化应激触发肝细胞的增殖. 这项研究表明,Schistosoma mansoni蛋诱导了这种反应,可能将寄生虫与肝脏损伤和癌症风险联系起来.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 寄生虫学的寄生虫学
- 分子生物学分子生物学
背景情况:
- 全球约有2.5亿人患有杆菌性疹.
- 曼索尼螺杆菌感染会导致肝损伤和氧化还原失衡,可能会增加癌症风险.
研究的目的:
- 为了调查氧化压力是否会在Schistosoma mansoni感染期间引起肝细胞增殖.
- 阐明将寄生虫感染与肝细胞变化的机制.
主要方法:
- 在受感染的仓鼠肝脏中分析细胞周期,复制应激和转录和蛋白质水平的增殖标记.
- 在体外实验中,使用人类肝瘤细胞与S. mansoni可溶性卵抗原进行了实验.
- 在感染患者的人体活检样本中验证发现.
主要成果:
- 曼索尼菌感染诱导了DNA复制许可因子,细胞循环环林和肝细胞中的DNA损伤反应.
- 即使是来自单性感染的慢性炎症过程也适度激活了细胞循环标记物.
- S. mansoni可溶性卵抗原刺激了人类肝瘤细胞的增殖,而这种增殖被减少的谷氨抑制了.
结论:
- 建议S. mansoni感染中的肝细胞增殖是由卵诱导的氧化应激引发的.
- 氧化应激是一种关键的媒介,将寄生虫感染与肝细胞增殖联系起来.
更多相关视频
09:58Using Eggs from Schistosoma mansoni as an In vivo Model of Helminth-induced Lung Inflammation
Published on: June 5, 2012
13.8K
00:06An Oncogenic Hepatocyte-Induced Orthotopic Mouse Model of Hepatocellular Cancer Arising in the Setting of Hepatic Inflammation and Fibrosis
Published on: September 12, 2019
8.9K
相关概念视频
01:24Liver Regeneration
3.3K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
3.3K
02:23Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K