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相关概念视频

Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)00:53

Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)

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Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...
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Step-Growth Polymerization: Overview01:03

Step-Growth Polymerization: Overview

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Step-growth or condensation polymerization is a stepwise reaction of bi or multifunctional monomers to form long-chain polymers. As all the monomers are reactive, most of the monomers are consumed at the early stages of the reaction to form small chains of reactive oligomers, which then combine to form long polymer chains in the late stages. Hence, the reaction has to proceed for a long time to achieve high molecular weight polymers.
Many natural and synthetic polymers are produced by...
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Types of Step-Growth Polymers: Polyesters01:20

Types of Step-Growth Polymers: Polyesters

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The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the...
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Anionic Chain-Growth Polymerization: Overview01:20

Anionic Chain-Growth Polymerization: Overview

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The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
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Polymer Classification: Architecture01:14

Polymer Classification: Architecture

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Polymers are classified as linear or branched on the basis of their chain architecture. The polymer chains in linear polymers have a long chain-like structure with minimal to no branching at all. Even if a polymer features large substituent groups on the monomer, which appear as branches to the skeleton, it is not considered a branched polymer. A branched polymer contains secondary polymer chains that arise from the main polymer chain. The branching occurs when the polymer growth shifts from...
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相关实验视频

Updated: Jul 16, 2025

Fabricating Degradable Thermoresponsive Hydrogels on Multiple Length Scales via Reactive Extrusion, Microfluidics, Self-assembly, and Electrospinning
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适应性聚合平台用于可调节生物降解的治疗药物.

M Hrochová1, L Kotrchová1, M Frejková1

  • 1Institute of Macromolecular Chemistry, Czech Academy of Sciences, Prague 16200, Czechia.

Acta biomaterialia
|September 11, 2023
PubMed
概括
此摘要是机器生成的。

一个新的可适应的聚合平台使生物可降解的聚合物生物材料用于药物输送. 这些先进的材料提供了可控的降解,增强了药物循环,并改善了抗瘤疗效,并减少了副作用.

关键词:
在CTA中,CTA是CTA.药物输送是药物输送的过程.这是HPMA的HPMA.聚合物载体是一种聚合物载体.在RAFT的聚合物化过程中,

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科学领域:

  • 生物材料科学 生物材料科学
  • 聚合物化学 聚合物化学
  • 纳米医学是一种纳米医学.

背景情况:

  • 基于生物降解的聚合物治疗药物对于提供生物活性化合物至关重要.
  • 现有的材料需要优化循环,药理动力学,生物降解性和分泌.
  • 需要适应性平台来创建先进的药物输送系统.

研究的目的:

  • 开发一种可适应的聚合平台,用于合成长循环,刺激敏感和可生物降解的生物材料.
  • 创建聚合物药物合物,以提高治疗效果和有针对性的治疗.
  • 为了验证平台的实用性,使用一种抗癌药物,pirarubicin.

主要方法:

  • 设计和合成了四种链传递剂 (CTA) 用于可逆的添加-碎片化链传递聚合.
  • 合成的水解生物降解区块共聚合物具有可调节的降解率 (5小时至21天).
  • 通过pH敏感的酸键将合皮拉鲁比辛 (THP) 结合到聚合物生物材料中.

主要成果:

  • 控制的聚合实现了可调节的水解性降解半衰期.
  • 与线性结合物相比,聚合物结合物显示出更高的抗瘤疗效.
  • 可生物降解系统显著增加了THP的血液循环半衰期 (几乎是两倍).

结论:

  • 开发的平台可以合成先进的可生物降解的聚合物生物材料,用于药物输送.
  • 该平台允许调整生物降解性,对刺激敏感的药物结合,以及优化的药理动力学.
  • 这种方法有助于创建有针对性的或异位聚合物合物,以改善治疗.