在典型的阅读网络中具有适应性短期可塑性.
S Turker1, P Kuhnke1, F R Schmid2
1Lise Meitner Research Group Cognition and Plasticity, Max Planck Institute for Human Cognitive and Brain Sciences, Stephanstr. 1a, Leipzig 04103, Germany; Wilhelm Wundt Institute for Psychology, University of Leipzig, Germany.
NeuroImage
|September 11, 2023
概括
这项研究使用了跨磁刺激 (TMS) 来研究典型的读者左側角-角皮質 (TPC). 研究结果表明,TMS可以改变大脑网络连接,可能有助于阅读障碍干预.
科学领域:
- 神经科学是一个神经科学.
- 认知神经科学 认知神经科学
- 心理语言学 心理语言学
背景情况:
- 在阅读过程中,左侧角-角皮层 (TPC) 对于语音解码和音字映射至关重要.
- 在阅读障碍症患者中观察到TPC活动的减少,这突显了它在阅读获取方面的重要性.
- 了解TPC的因果作用可以为阅读困难的干预提供信息.
研究的目的:
- 调查左TPC对典型成年人阅读的因果关系.
- 探索如何通过TPC进行跨磁刺激 (TMS) 调节大脑的阅读网络.
- 为潜在的阅读障碍干预确定TMS诱导的变化的神经相关物.
主要方法:
- 28名典型的成年阅读者在执行阅读任务时接受了功能磁共振成像 (fMRI).
- 参与者在左TPC上接受了有效或假的TMS.
- 用单变量,多变量分析和动态因果建模来评估大脑活动和连接性.
主要成果:
- 观察到TMS对阅读表现和大脑激活的影响的个体变化.
- 对左TPC的有效TMS在伪词阅读期间诱导左下额叶皮质激活的转移.
- TMS增强了从左腹尾皮层到左TPC的有效连接.
结论:
- 尽管对阅读表现没有直接影响,但TMS在阅读网络中引发了短期的补偿性重组.
- 观察到的与任务相关活动的变化和功能合的增加表明网络适应.
- 这项研究提供了远程刺激效应的证据,以及功能相互作用在阅读中的意义.
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