新的制阻燃剂BTBPE对甲状腺毒性的影响和机制
Qiong Zhang1, Zhenyu Wang1, Qianqian Xiao1
1Department of Toxicology, School of Public Health, Peking University, Beijing, 100191, PR China; Beijing Key Laboratory of Toxicological Research and Risk Assessment for Food Safety, Beijing, 100191, PR China.
概括
1,2-bis(2,4,6-tribromophenoxy) 乙 (BTBPE),是一种阻燃剂,可能会损害甲状腺功能. 研究表明,BTBPE暴露会降低甲状腺激素和关键合成蛋白质在体内和体外,这表明潜在的人类健康风险.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 内分泌学 在内分泌学.
背景情况:
- 像octa-BDE这样的制阻燃剂 (BFR) 已知具有甲状腺毒性.
- 1,2-bis(2,4,6-tribromophenoxy) 乙烯 (BTBPE) 是一种广泛使用的替代BFR.
- BTBPE的甲状腺毒性在很大程度上仍然没有被描述.
研究的目的:
- 调查BTBPE的体内和体外甲状腺毒性.
- 评估BTBPE对甲状腺激素水平和合成途径的影响.
- 评估BTBPE暴露对人类健康的潜在影响.
主要方法:
- 鼠在体内暴露于不同剂量的BTBPE.
- 使用人类甲状腺细胞进行体外研究 (Nthy-ori 3-1).
- 分析甲状腺激素水平 (FT4,TT4) 和关键蛋白质/基因表达 (TG,TPO,NIS,PAX8,TTF1,TTF2) 通过西斑和RT-PCR.
主要成果:
- 在体内:BTBPE暴露降低了FT4和TT4水平.
- 在体内:甲状腺激素合成标记物 (TG,TPO,NIS) 和调控因子 (PAX8,TTF2) 的蛋白质和基因表达减少.
- 在体外:BTBPE降低了PAX8,TF1,TF2,随后抑制了TG和NIS,反映了体内发现.
结论:
- 暴露于BTBPE会干扰甲状腺激素T4生成.
- 在动物模型和人类细胞中,BTBPE表现出潜在的甲状腺毒性作用.
- BTBPE可能会导致内分泌干扰,因此需要进一步调查人类健康风险.
更多相关视频
16:02Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
Published on: February 10, 2023
2.7K
07:08Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants
Published on: March 6, 2018
6.1K
相关概念视频
01:20Synthesis and Regulation of Thyroid Hormones
4.7K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.7K
01:18Functions of Thyroid Hormones
2.8K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.8K
01:26Toxic Reactions: Overview
1.0K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
1.0K
01:17Hormones and Bone Tissue
2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
02:59Biological Effects of Radiation
15.5K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
15.5K
01:07Teratogenicity
2.5K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.5K