美国查加斯病的临床特征和结果:多中心回顾分析
Andrés F Henao-Martínez1, Christian Olivo-Freites2, Nelson I Agudelo Higuita3,4
1Division of Infectious Diseases, Department of Medicine, University of Colorado Denver, Aurora, Colorado.
The American journal of tropical medicine and hygiene
|September 11, 2023
概括
查加斯病在美国影响了30万人. 慢性查加斯心肌病症对心律失常,中风和死亡率具有重大风险,这强调了早期查和治疗的必要性.
科学领域:
- 传染性疾病 传染性疾病
- 心脏病学 心脏病学
- 流行病学 流行病学
背景情况:
- 查加斯病在美国影响了30万个人.
- 慢性查加斯病的临床特征和结果需要进一步研究.
- 了解疾病进展对于患者管理至关重要.
研究的目的:
- 在美国多中心网络中评估慢性查加斯病的临床特征和结果.
- 评估不同形式的查加斯病中心肌病和其他并发症的风险.
- 为了确定查加斯病的流行率和美国的治疗模式.
主要方法:
- 使用TriNetX研究网络进行的回顾性队列研究.
- 确定的患者具有双阳性Trypanosoma cruzi IgG血清学.
- 在长达5年的随访中捕获的临床结果.
主要成果:
- 确定了429名具有正确的查加斯血清学患者 (2,2%的测试).
- 不确定形式的心肌病风险为每年1.3%;CCC显示心律失常的年风险为1.6%和中风的年风险为0.8%.
- 每年CCC死亡率为2.7%,住院率为17.1%;只有13名患者接受了抗松体治疗.
结论:
- 慢性查加斯心肌病变症带来了相当大的负担,增加了发病率和死亡率.
- 在美国的风险人群中,查加斯病的查至关重要.
- 记录了有限的抗松体治疗,突出了护理上的差距.
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