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Updated: Jul 16, 2025

Protocols for Analyzing the Role of Paneth Cells in Regenerating the Murine Intestine using Conditional Cre-lox Mouse Models
07:48

Protocols for Analyzing the Role of Paneth Cells in Regenerating the Murine Intestine using Conditional Cre-lox Mouse Models

Published on: November 21, 2015

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通过HuR控制帕内斯细胞功能,通过改变干细胞活性来调节肠道粘膜的生长

Lan Xiao1, Bridgette Warner1, Caroline G Mallard1

  • 1Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD, USA.

Life science alliance
|September 11, 2023
PubMed
概括

RNA结合蛋白 HuR 通过维持 Paneth 细胞 (PC) 利基信号,对肠道干细胞 (ISC) 功能至关重要. 被破坏的HuR会损害PC/ISC的利基完整性,导致肠道粘膜缩.

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