喉扩大和通过呼气压力训练进行适当的通风可以提高COPD的有氧能力:一项随机对照试验
Keisuke Miki1, Kazuyuki Tsujino2, Motonari Fukui3
1Department of Respiratory Medicine, National Hospital Organization Osaka Toneyama Medical Center, Toyonaka, Japan miki.keisuke.pu@mail.hosp.go.jp.
Thorax
|September 11, 2023
概括
呼吸压力负荷训练 (EPT) 通过扩大喉,改善了慢性阻塞性肺病 (COPD) 患者的运动耐受性. 这种新的方法提高了有氧能力和耐力,即使在严重的COPD病例中也是如此.
科学领域:
- 肺部医学 肺部医学
- 呼吸系统生理学 呼吸系统生理学
- 运动科学 运动科学
背景情况:
- 外围气道阻塞策略不充分改善COPD中的运动不耐受性.
- 喉狭窄是一个潜在的,未被探索的因素,有助于COPD运动不耐受.
研究的目的:
- 调查呼吸压力负荷训练 (EPT) 作为一种针对喉收窄的新型干预措施,以改善COPD患者的运动不耐受.
- 评估EPT对运动能力,喉功能和通风参数在不同严重程度的COPD的影响.
主要方法:
- 一项为期3个月的随机对照试验,涉及47名COPD患者 (GOLD I-IV),分配给EPT或对照组.
- 主要结果:耐力时间在恒定工作速率运动测试中 (GOLD III-IV). 二次结果:氧气吸收峰值,喉功能和通风效率.
- 喉收窄是通过喉镜在亚最大运动期间评估的.
主要成果:
- 与对照组相比,EPT在GOLD I-II (+703s) 和GOLD III-IV (+390s) COPD患者中显著增加了耐力时间.
- EPT增强了峰值氧气吸收 (p<0.009在GOLD I-II中,p<0.0005在GOLD III-IV中) 和喉扩张比 (p<0.007在GOLD I-II中,p<0.0002在GOLD III-IV中).
- 喉扩张和通风效率的改善与分别提高峰值氧气吸收和耐力时间的相关性.
结论:
- 呼吸压力负荷训练有效地提高了COPD患者的有氧能力和耐力时间.
- EPT通过增加喉扩张和改善通风来实现这些好处,即使是在COPD的晚期阶段.
- 用EPT准喉功能是治疗COPD运动不耐受的一个有希望的治疗策略.
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