在健康的俄罗斯人口中基于模型评估CAVI的参考值,并与CAVI0进行基准测试
Tatiana Safronova1, Anna Kravtsova2,3, Sergei Vavilov2
12nd Internal Medicine Department, I.M. Sechenov First Moscow State Medical University, Moscow, Russia.
American journal of hypertension
|September 11, 2023
概括
心血管指数 (CAVI) 和CAVI0是可靠的动脉硬度标志物. 这项研究分析了俄罗斯成年人的CAVI/CAVI0,发现年龄是关键预测因素,并提出了参考值计算工具.
科学领域:
- 心血管研究的心血管研究.
- 生物医学工程 生物医学工程
- 公共卫生 公共卫生
背景情况:
- 心血管指数 (CAVI) 和CAVI0是动脉硬的非侵入性标志物.
- 以前的评估主要是在日本人口中进行的.
- 本研究的重点是俄罗斯队列评估这些标记.
研究的目的:
- 在健康的俄罗斯受试者中分析人口特征和CAVI/CAVI0值之间的关联.
- 提出一个工具来计算CAVI和CAVI0.0的参考范围.
- 扩大对不同人群中动脉硬度标志物的理解.
主要方法:
- 分析了742名俄罗斯健康志愿者的数据 (平均年龄30.4岁,73.45%是男性).
- 在R软件中利用了包括ANOVA,皮尔森相关性和多变量线性回归在内的统计分析.
- 共同变量包括年龄,性别,BMI,血压和心率 (HR).
主要成果:
- 在CAVI和CAVI0.0中没有发现基于性别的显著差异.
- 这两个指数都显示出与年龄的积极关联 (r=0.49对于CAVI,r=0.43对于CAVI,P<0.001).
- 观察到与年龄相关的增加,但没有明确区分20-30岁和30-40岁的人. HR和血压是显著的预测因素,但临床意义有限.
结论:
- 在俄罗斯成年人中建立了人口特征和CAVI/CAVI0之间的定量关联.
- 开发了一种用于估计主体级参考CAVI和CAVI0测量的方法.
- 提出了一个算法来计算基于年龄,HR和脉压的预期CAVI范围.
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