杜申肌力发育不良的儿童体位变化可以预测睡眠低通风吗?
C Pandit1, B Kennedy2, K Waters1
1Department of Respiratory Medicine, The Children's Hospital at Westmead, Sydney, NSW, Australia; Discipline of Child and Adolescent Health, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
Paediatric respiratory reviews
|September 11, 2023
概括
患有杜恩肌肉发育不良症 (DMD) 的儿童在从坐到躺转移时会经历更大的肺功能变化. 然而,卧底肺功能下降并不能预测这些患者的睡眠低通风.
科学领域:
- 儿科肺病学 儿科肺病学
- 神经肌肉疾病 神经肌肉疾病
- 睡眠医学 睡眠医学
背景情况:
- 杜氏肌肉发育不良 (DMD) 是一种进展性神经肌肉疾病,影响呼吸肌肉.
- 姿势变化可以显著影响肺功能,特别是在肌肉软弱的个体.
- 多睡眠学 (PSG) 用于评估与睡眠相关的呼吸障碍.
研究的目的:
- 研究患有DMD的儿童肺功能姿势变化和多睡眠学 (PSG) 发现之间的关系.
- 为了确定卧卧的螺旋测量测量是否与DMD患者的睡眠低通风相关.
主要方法:
- 一项涉及DMD儿童和健康儿童对照组的前性横截面研究.
- 对所有参与者进行了坐姿和卧姿的螺旋测量.
- 在六个月内对DMD患者进行螺旋测量,进行了多睡眠图像 (PSG).
主要成果:
- 与健康对照组相比,患有DMD的儿童在坐姿和卧姿之间强迫活力能力 (FVC) 的变化明显更大 (9%与4%,P <0.001).
- 在17名DMD儿童中,有14人 (84%) 进行了可接受的卧底螺旋测量;平均FEV1和FVC预测分别为77%和74%.
- FVC (ΔFVC(sit-sup)) 的变化与多睡眠学参数的相关性很差,包括总呼吸暂停-呼吸暂停指数 (AHI) 和REM AHI.
结论:
- 与健康同龄人相比,患有DMD和轻度限制性肺病的儿童在螺旋测量上表现出更明显的姿势效应.
- 在DMD患者的卧底螺旋体检结果没有被发现可以预测PSG检测到的睡眠低通风.
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