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Updated: Jul 16, 2025

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在KrasG12D背景下,CBX4删除通过诱导基因组不稳定性来促进瘤发生

Fangzhen Chen1, Wulei Hou2, Xiangtian Yu3

  • 1Department of Human Anatomy and Histoembryology, School of Basic Medical Sciences and Shanghai Xuhui Central Hospital, Shanghai Medical College, Fudan University, Shanghai, 200030, China.

Signal transduction and targeted therapy
|September 11, 2023
PubMed
概括

染色体蛋白同类4 (CBX4) 删除促进肺腺癌 (LUAD) 通过引起基因组不稳定性在Kras-突变细胞. 失去CBX4与Kras突变的LUAD患者的预后较差有关.

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