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Updated: Jul 16, 2025

Efficient PAM-Less Base Editing for Zebrafish Modeling of Human Genetic Disease with zSpRY-ABE8e
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一个分裂和可诱导的腺基编辑器,用于精确的体内基编辑

Hongzhi Zeng1, Qichen Yuan1, Fei Peng2

  • 1Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX, 77005, USA.

Nature communications
|September 11, 2023
PubMed
概括

研究人员开发了一种分裂腺基编辑器 (sABE),用于精确的DNA编辑. 这种新系统使用化学诱导的二分化来控制基编辑器活动,为潜在的治疗应用提供更高的精度和更少的非目标效应.

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