细胞治疗中白血病后波动性高血症的风险分析
Tomoyasu Jo1,2,3, Yasuyuki Arai4,5,6, Toshio Kitawaki2
1Center for Research and Application of Cellular Therapy, Kyoto University Hospital, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, 606-8507, Japan.
Scientific reports
|September 11, 2023
概括
在白血病化过程中优化补充剂是患者安全的关键. 减缓血液处理,而不是增加,可以在CAR T细胞疗法等程序后预防危险的高血症.
科学领域:
- 血液学 血液学 血液学
- 输血医学 输血医学
- 临床化学 临床化学
背景情况:
- 酸盐诱导的低血是白血病发生期间的风险.
- 安全的白血病需要优化水平的管理.
研究的目的:
- 为了评估血清电离 (iCa) 度在白血病化过程中和之后.
- 为了确定影响白血病后高血症的因素.
- 在白血病发生过程中制定安全的管理策略.
主要方法:
- 对76名接受细胞疗法白血过敏治疗的患者进行前性分析.
- 持续的静脉糖酸补充剂,每小时进行ICA监测.
- 多变量分析以确定白血病后高血症的预测因素.
主要成果:
- 在76.3%的受试者中发生过高血症 (iCa>上限1小时后的白血病).
- 较高的加工血液体积与体重比率,快速的输注,以及低端白血iCa预测了术后的高血症.
- 开发了一种预测公式和图表,用于白血病后iCa.
结论:
- 可以估计最佳的iCa目标和补充率.
- 建议在增加补充剂时减缓血液处理速度,以获得高处理量与体重的比率,以防止高血症.
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