天生的淋巴细胞在粘膜屏障中的多功能作用:从恒常状态到病理性炎症
Seungwon Ryu1, MinYeong Lim2,3,4, Jinwoo Kim2,3,4
1Department of Microbiology, Gachon University College of Medicine, Incheon, 21999, South Korea.
Experimental & molecular medicine
|September 11, 2023
概括
天生的淋巴细胞 (ILC) 是粘膜免疫和疾病的关键参与者. 研究强调了ILCs.
科学领域:
- 免疫学 免疫学 免疫学
- 细胞生物学 细胞生物学
背景情况:
- 天生的淋巴细胞 (ILC) 是对粘膜免疫至关重要的淋巴细胞,缺乏抗原特异性受体.
- ILCs根据其转录因子和细胞因子的产生被分为三组 (ILC1-3),反映T辅助细胞子集.
- 这些细胞与粘膜疾病的发展和解决有关,特别是在呼吸系统和肠道.
研究的目的:
- 审查了解粘膜健康和疾病中的先天性淋巴细胞 (ILC) 生物学方面的最新进展.
- 探索调节ILC活动的免疫检查点及其作为治疗点的潜力.
- 总结针对ILC的当前治疗策略,并研究细胞治疗方法.
主要方法:
- 关于ILC生物学和功能的最近研究的文献综述.
- 对免疫检查点及其在ILC调控中的作用的研究分析.
- 对针对ILCs的已批准和正在研究药物的调查.
- 探索监管ILC细胞疗法的新兴研究.
主要成果:
- 在粘膜疾病中,ILCs起着双重作用,有助于病原和解决.
- 免疫检查点为调节疾病中的ILC活动提供了潜在的目标.
- 许多针对ILC的药物正在临床试验中,用于粘膜疾病.
- 监管ILCs代表了基于细胞的疗法的一个有前途的领域.
结论:
- 针对ILCs为粘膜疾病提供了各种治疗机会.
- 对ILC调节和细胞疗法的进一步研究是有必要的.
- 了解ILC对于开发用于粘膜炎症疾病的新疗法至关重要.
相关概念视频
01:18Lymphoid Cells and Tissues
1.2K
Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
1.2K
01:15Secondary Lymphoid Organs
1.6K
Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
1.6K
01:28Functions of the Lymphatic and Immune System
3.7K
The lymphatic system plays a crucial role in bolstering our immune system. It consists of a network of lymphoid organs, lymph, and lymphatic vessels that provide structural and functional support in safeguarding the body against pathogens such as viruses and bacteria.
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
3.7K
01:22Introduction to Lymphatic and Immune System
2.8K
Immunity is a crucial biological concept about our body's inherent capacity to prevent infections and diseases. A complex network of cells and tissues collectively known as the immune system facilitates this natural defense mechanism. The immune system plays an integral role in maintaining our health and well-being, shielding us from potential health threats.
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
The immune responses can be categorized into two types: innate and adaptive. Innate immunity comprises nonspecific defenses we are...
2.8K
01:21Introduction to Innate and Adaptive Immunity
4.1K
The human immune system is a complex defense mechanism that protects the body from harmful pathogens and foreign substances. It comprises two crucial components: innate and adaptive immunity.
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
Innate immunity is the body's natural, nonspecific defense system that acts quickly to protect against pathogens. It incorporates physical barriers like skin and mucous membranes and cellular elements such as phagocytes and natural killer cells. This part of our immune system provides an immediate,...
4.1K
01:28Inflammatory Response
2.1K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
2.1K