肥胖引起的和减肥引起的生理因素影响重量恢复
Marleen A van Baak1, Edwin C M Mariman2
1NUTRIM School for Nutrition and Translational Research in Metabolism, Department of Human Biology, Maastricht University, Maastricht, Netherlands. m.vanbaak@maastrichtuniversity.nl.
Nature reviews. Endocrinology
|September 11, 2023
概括
在生活方式干预后恢复体重是一个主要的挑战. 了解荷尔蒙因素和能量消耗等生理机制是制定有效肥胖管理策略的关键.
科学领域:
- 生理学 生理学 生理学
- 代谢过程中的代谢.
- 肥胖问题研究研究
背景情况:
- 干预后重拾体重在管理超重和肥胖方面是一个重大挑战.
- 确定因果机制对于开发有效的体重管理策略至关重要.
- 肥胖与代谢和心血管并发症有关.
研究的目的:
- 审查目前对体重减轻后体重恢复背后的生理机制的理解.
- 讨论这些机制的肥胖相关变化如何在减肥和恢复期间持续存在.
- 审查旨在预防或限制重量恢复的干预措施.
主要方法:
- 关于生理机制的文献综述.
- 对荷尔蒙,神经元和代谢因素的分析.
- 脂肪组织免疫细胞和能量消耗的检查.
主要成果:
- 关键机制包括脂肪组织免疫力,胃口和奖励的荷尔蒙/神经元调节,休息能量消耗和适应性热生成.
- 这些系统中与肥胖相关的变化在减肥后持续存在,有助于恢复体重.
- 诸如饮食,运动和药物治疗之类的干预措施显示出可变的有效性.
结论:
- 了解持续的生理变化对于应对重量恢复至关重要.
- 针对这些机制为新的肥胖管理策略提供了潜力.
- 需要进一步的研究来优化长期体重管理的干预措施.
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