细菌 velezensis DSM 33864减少了Clostridioides difficile的殖民,而不会扰乱开始性肠道微生物群的组成
Ida Søgaard Larsen1, Megan Chenaux2, Fergus W J Collins3
1Novozymes A/S, Bagsværd, Denmark.
Scientific reports
|September 11, 2023
概括
细菌 velezensis DSM 33864 有效地减少了在肠道中的困难 Clostridioides 殖民. 这种益生菌候选物显示出预防感染的前景,而不会对有益的肠道细菌产生负面影响.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 益生菌 益生菌 益生菌
背景情况:
- 艰难殖民性的Clostridioides影响到25%的美国人口.
- 抗生素的使用破坏了肠道微生物群,使得C. difficile的机会性感染成为可能.
- 针对C. difficile的殖民对有风险的个体至关重要.
研究的目的:
- 识别和描述一个益生菌候选人,以减少C. difficile的殖民化.
- 评价Bacillus velezensis DSM 33864对C. difficile的疗效. 这种药物有什么作用?
- 评估B. velezensis DSM 33864对肠道微生物群的影响.
主要方法:
- 在体外测试B. velezensis DSM 33864对C. difficile进行检测.
- 使用人类便介质进行体外测试.
- 在体内研究中,健康的和用克林达米辛治疗的C. difficile殖民的小鼠模型.
主要成果:
- B. velezensis DSM 33864在体外和人类便样本中显著减少了C. difficile的殖民化.
- 口服B. velezensis DSM 33864子降低了克林达米辛治疗小鼠中的C. difficile水平.
- B. velezensis DSM 33864没有影响体外或体内共生微生物群的组成.
结论:
- 细菌 velezensis DSM 33864是一种有前途的益生菌,可以减少C. difficile的殖民.
- 口服B. velezensis DSM 33864在体内有效降低了C. difficile的水平.
- 这种益生菌候选人提供了有针对性的方法,而不会破坏本地肠道微生物群.
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