高龄患者的甘油三-葡萄糖指数和化大动脉狭窄之间的关联:一个横截面研究
Zhihui Hu1, Tiantian Xiong2, Chunling Chen3
1The Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Scientific reports
|September 11, 2023
概括
胰岛素耐药性 (IR),由甘油三-葡萄糖 (TyG) 指数表示,在老年患者中与化大动脉狭窄 (CAS) 呈负相关性. 这一发现表明代谢功能障碍与大动脉膜疾病进展之间存在潜在联系.
科学领域:
- 心脏病学 心脏病学
- 代谢综合征是代谢综合征的一种.
背景情况:
- 胰岛素抵抗 (IR) 是心血管疾病的一个已知的危险因素.
- 关于IR和化大动脉狭窄症 (CAS) 之间的关联存在有限的研究.
研究的目的:
- 为了研究三甘-葡萄糖 (TyG) 指数之间的相关性,IR的标志物,和老年人中CAS的存在.
主要方法:
- 一项涉及183名老年患者的病例控制研究,这些老年患者通过横心心回声学诊断出CAS.
- 一组没有AS的老年患者的对照组,年龄和性别相匹配1:1.
- 使用多变量逻辑回归,曲线拟合和趋势测试来分析TyG指数和CAS之间的关系.
主要成果:
- 当作为连续变量分析时,TyG指数被发现与CAS负相关 (P < 0.001).
- 曲线拟合和趋势测试证实了TyG指数和CAS之间的负相关性.
- 这表明,较高的TyG指数值与CAS的可能性较低相关.
结论:
- 甘油三糖 (TyG) 指数与老年人中化大动脉狭窄有负相关性.
- 这种关联可能归因于胰岛素抵抗对胰岛素受体和信号通路的有害影响.
- 需要进一步的研究来阐明将IR和CAS联系在一起的潜在机制.
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