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目标平均总偏差趋势分析的实用性,用于检测早期至中度阶段光眼的渐进性视野变化

Woo Keun Song¹, Ko Eun Kim¹, Anna Lee¹

¹Department of Ophthalmology, University of Ulsan, College of Medicine, Asan Medical Center, Seoul, Korea.

Eye (London, England)

|September 11, 2023

概括

基于趋势的目标平均总偏差 (TMTD) 分析检测到视野进展的速度更快,更灵敏地比平均总偏差 (mTD) 在青光眼患者. 这种方法可以在早期到中度阶段更好地检测青光眼的进展.

科学领域:

眼科医生眼科眼科
医学诊断医学诊断医学诊断
视觉科学视觉科学

背景情况:

玻璃眼是一种渐进的视神经病变,导致不可逆转的视力丧失.
早期检测和视野 (VF) 进展的监测对于控制青光眼的管理至关重要.
目前用于VF分析的方法可能在检测早期到中度阶段的微妙变化方面存在局限性.

研究的目的:

为了比较基于趋势的目标平均总偏差 (TMTD) 分析与平均总偏差 (mTD) 分析的临床实用性.
评估VF变化速率和在TMTD和mTD之间检测VF进展的灵敏度.
为了评估这些指标在早期到中度青光眼患者与 hemifield VF 缺陷.

主要方法:

追溯评估139个开角绿眼病患者的VF缺陷和至少两年的随访.
TMTD是通过平均总偏差 (TD) 值来计算的,不包括基线测试中<0 dB灵敏度的点.
mTD是通过计算所有VF TD值的平均值来计算的.
用基于事件和趋势的分析将患者分类为进展者或非进展者.

主要成果:

基于趋势的TMTD分析表明,与mTD相比,全球和VF受影响的半球场的变化速度明显更快 (P < 0.001).
基于趋势的TMTD分析在更大比例的患者中 (38.1%) 检测到VF进展,而不是基于趋势的mTD (30.2%) 和基于事件的分析 (27.3%) 在受影响的半球中.
该研究包括49名进步者和90名非进步者.

结论:

对于TMTD的变化速度明显快于mTD,无论是全球还是受影响的半球场.
与基于趋势的mTD和基于事件的分析相比,基于趋势的TMTD分析在检测VF进展方面具有更高的灵敏度.
TMTD分析是监测患有 Hemifield 损失的患者的 DrDeramus 进展的一个有价值的工具.

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