相关实验视频

Updated: Jul 16, 2025

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody

Published on: May 16, 2020

Fc工程单克隆抗体,以减少非目标肝脏吸收

Tristan Mangeat¹, Matthieu Gracia¹, Alexandre Pichard¹

¹Institut de Recherche en Cancérologie de Montpellier (IRCM), Inserm U1194, Université de Montpellier, ICM, 34298, Montpellier, France.

EJNMMI research

|September 11, 2023

概括

放射性标记抗体中的Fc沉默减少了肝脏积累,改善了瘤向. 这种修改增强了抗体的生物分发,从而改善了神经应用.

科学领域:

免疫学免疫学免疫学
放射化学放射化学是指辐射化学.
在瘤学瘤学.

背景情况:

放射性标记的抗体通常显示出非特异性肝脏积累,阻碍图像分析和生物分布.
Fc玛受体 (FcγR) 的结合与这种不必要的肝脏吸收有关.

研究的目的:

调查Fc沉默对抗体生物分布的影响.
为了比较野生型Fc抗体与Fc突变抗体 (LALAPG三重突变) 的性能.

主要方法:

产生了具有野生类型和突变Fc的重组89Zr标记的人类IgG1抗体.
用PET-CT和常规方法分析了瘤异种移植的小鼠中的抗体生物分布.

主要成果:

与野生型Fc抗体相比,突变Fc抗体的肝脏积累显著减少.
用Fc突变抗体增加了瘤特异性向,从而提高了瘤与肝脏的比率.

结论:

通过Fc沉默来减少FcγR结合,降低了放射性标记抗体的肝脏积累.
Fc静音提供了一种有前途的策略,通过增强瘤向和图像质量来改进基于抗体的治疗方法.

关键词:

在Fc Fc Fc Fc玛受体的使用方法这种突变是LALAPG突变.远离目标,远离目标在PET-CT中使用.

更多相关视频

A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity

A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity

Published on: July 12, 2018

Stabilizing Hepatocellular Phenotype Using Optimized Synthetic Surfaces

Stabilizing Hepatocellular Phenotype Using Optimized Synthetic Surfaces

Published on: September 26, 2014

相关概念视频

Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...