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Updated: Jul 16, 2025

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在单细胞中直接测量工程癌症突变及其转录表型

Heon Seok Kim1,2,3, Susan M Grimes1, Tianqi Chen1

  • 1Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA.

Nature biotechnology
|September 11, 2023
PubMed
概括

这项研究引入了TISCC-seq,这是一种新的单细胞技术,可以精确地将癌症突变与它们对基因表达的影响联系起来. 这种方法有助于分类100多个TP53突变在细胞系中的功能影响.

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Cancers Originate from Somatic Mutations in a Single Cell02:21

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Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
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