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25-基维生素D与2型糖尿病患者腹部肥胖的岛屿恒温有关
Qing Li1, Wen Zhang1, Bing Han1
1Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, 200011, China.
维生素D水平与2型糖尿病患者,特别是腹部肥胖患者的岛屿功能更好有关. 较高的25-氧维生素D (25(OH) D与较低的葡萄糖和C-相关,表明改善了岛屿平衡.
科学领域:
- 内分泌学 在内分泌学.
- 代谢疾病 代谢疾病
- 营养科学 营养科学
背景情况:
- 岛屿的α (α) 和β (β) 细胞功能对于维持葡萄糖平衡至关重要.
- 2型糖尿病 (T2D) 的特点是胰岛素分泌受损和葡萄糖失调.
- 维生素D在小岛功能中的作用及其与T2D的关联需要进一步研究.
研究的目的:
- 研究2型糖尿病患者血清25-基维生素D[25(OH) D]水平与小岛功能恒温的相关性.
- 根据腹部肥胖的存在或不存在来探索这种关联中的潜在差异.
主要方法:
- 一项涉及4670名来自中国上海的T2D患者的队列研究.
- 测量人类指数,生物化学参数,血清25(OH) D和岛屿功能标志物 (C-和葡萄糖).
- 统计分析包括回归和调解分析,按腹部肥胖状况分层.
主要成果:
- 在T2D患者中,血清25(OH) D水平与禁食血葡萄糖 (FPG),糖化血红蛋白 (HbA1c),葡萄糖和C-具有负相关性.
- 在患有腹部肥胖症的患者中,25(OH) D与HbA1c,葡萄糖,HOMA-IR,基线胰岛素和C-显著相关.
- 25 (((OH) D通过其对葡萄糖的作用,部分影响了C-水平,并观察到显著的相互作用效应.
结论:
- 血清25(OH) D与T2D患有腹部肥胖症的患者的葡萄糖和C-具有负相关性.
- 维生素D影响C-分泌,部分是通过调节葡萄糖水平.
- 在患有腹部肥胖的T2D患者中,25(OH) D对葡萄糖/C-比的影响受糖尿病持续时间的影响,影响小岛恒温.
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