肠道微生物群和泌尿瘤之间的因果关系:一项两样本的门德尔随机化研究
Wang Mingdong1, Gao Xiang2, Quan Yongjun1
1Department of Urology, Beijing Tongren Hospital, Capital Medical University, Beijing, China.
BMC cancer
|September 11, 2023
概括
肠道微生物群失调与尿道癌症有关. 这项研究发现,像Bifidobacterium和Ruminococcustorques这样的特定细菌与膀,前列腺和癌的风险增加有关.
科学领域:
- 微生物组研究的研究.
- 癌症流行病学癌症流行病学
- 遗传学 是一个遗传学.
背景情况:
- 肠道微生物群失调与包括癌症在内的各种疾病有关.
- 肠道微生物群在膀癌 (BCa),前列腺癌 (PCa) 和癌 (KCa) 等尿道瘤中的作用正在调查中.
- 肠道微生物群失调和泌尿癌之间的因果关系仍然存在争议.
研究的目的:
- 调查肠道微生物群和泌尿癌 (BCa,PCa,KCa) 之间的潜在因果关系.
- 为了确定与发展BCa,PCa和KCa的风险相关的特定细菌特征.
主要方法:
- 利用了来自MiBioGen联盟 (18,340个样本) 的微生物组全基因组关联研究 (GWAS) 数据.
- 从FinnGen和PRACTICAL联盟的GWAS提取了BCa,KCa和PCa的结果数据.
- 使用逆变量加权或沃尔德比率方法进行两样本的门德尔随机化 (MR) 分析,包括灵敏度和反向MR分析.
主要成果:
- 双杆菌,行动细菌和鲁米诺菌组与BCa的风险增加有关.
- 阿里森氏菌与BCa和PCa风险降低有关.
- 鲁米诺科克克斯托克斯群和Erysipelatoclostridium因果关系与KCa的风险增加有关.
结论:
- 遗传预测的肠道微生物组成与BCa,PCa和KCa有因果关系.
- 确切的细菌特征被确定为特定泌尿癌类型的风险因素.
- 这项MR研究提供了证据,支持肠道微生物群在尿道恶性瘤中的病因作用.
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