长非编码RNA在慢性阻塞性肺病中的实用性:全面分析
Qi Lin1,2, Chaofeng Zhang3,4, Huixin Weng5
1Department of Pharmacy, The Affiliated Hospital of Putian University, Putian, Fujian Province, China. linqitc@hotmail.com.
BMC pulmonary medicine
|September 11, 2023
概括
长非编码RNAs (lncRNAs) 是慢性阻塞性肺病 (COPD) 的诊断生物标志物. 这一元分析证实了它们在早期和准确的COPD诊断以及作为治疗点方面的潜力.
科学领域:
- 肺部医学 肺部医学
- 分子生物学分子生物学
- 生物标志物发现发现
背景情况:
- 慢性阻塞性肺病 (COPD) 是全球主要的疾病和死亡原因.
- 由于微妙或严重的症状,目前的诊断方法可能无法及早或准确地检测COPD.
研究的目的:
- 评估慢性阻塞性肺病 (COPD) 的长非编码RNA (lncRNAs) 的诊断准确性.
- 确定潜在的lncRNAs作为COPD的诊断生物标志物和治疗点.
主要方法:
- 在电子数据库中进行了全面的文献搜索.
- 图书统计分析和VOSviewer用于数据可视化.
- 对17项研究的元分析评估了诊断准确性,使用聚合的灵敏度,特异性和诊断几率比率.
- QUADAS-2检查清单评估了研究质量;子组和元回归分析探索了异质性.
主要成果:
- 分析表明,lncRNAs在区分COPD患者与对照患者 (SEN:0.86,SPE:0.78) 和AECOPD与COPD (SEN:0.75,SPE:0.81) 中具有显著的诊断性能.
- 总结接收器操作特征曲线 (sROC) 下的面积超过0.8,表明整体诊断能力良好.
- 确定了41种与COPD相关的lncRNA,主要在细胞核和细胞质中,与扩散,入侵和预后有关.
- 标本类型和特定的lncRNAs影响了诊断准确性,有证据表明出版偏差.
结论:
- 长非编码RNAs (lncRNAs) 作为COPD的诊断生物标志物具有相当大的潜力.
- 这些lncRNAs也可以作为管理COPD的有价值的治疗点.
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