植物性饮食,遗传倾向和非酒精性脂肪肝疾病的风险
Yanling Lv1,2, Shuang Rong3,4, Yan Deng5,6
1Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, 430030, China.
BMC medicine
|September 11, 2023
概括
健康的植物性饮食可以降低非酒精性脂肪性肝病 (NAFLD) 的风险和肝脂肪,无论遗传倾向如何. 不健康的植物性饮食增加了NAFLD风险,强调了饮食质量的重要性.
科学领域:
- 营养流行病学 营养流行病学
- 胃肠病学 胃肠病学
- 遗传学 遗传学 是一个
背景情况:
- 非酒精性脂肪肝 (NAFLD) 是一个日益严重的健康问题.
- 强调植物性食品的饮食显示出减轻NAFLD风险的潜力.
- 有限的前性数据存在于植物性饮食,遗传因素和NAFLD发展之间的相互作用.
研究的目的:
- 调查植物性饮食模式与发展NAFLD的风险之间的纵向关联.
- 探索植物性饮食和遗传易感性对NAFLD发病率和肝脏脂肪积累的综合影响.
- 区分健康与不健康的植物性饮食成分对NAFLD风险的影响.
主要方法:
- 一项大规模的纵向队列研究 (英国生物库) 涉及159,222名参与者.
- 计算总体,健康和不健康的植物性饮食指数 (PDI,hPDI,UPDI).
- 使用考克斯模型和通用线性模型评估新发性NAFLD和肝脂肪含量 (MRI-PDFF),考虑多基因风险评分 (PRS).
主要成果:
- 对整体PDI和hPDI的更高遵守与NAFLD风险显著降低有关.
- 不健康的植物性饮食 (uPDI) 的摄入量增加与NAFLD风险增加和肝脂肪增加相关.
- 高hPDI和PRS之间的显著相互作用表明,高hPDI和低遗传易感性的人群中NAFLD风险最低.
结论:
- 植物性饮食,特别是健康的饮食模式,与较低的NAFLD风险和肝脏脂肪含量有关.
- 不健康的植物性饮食选择与NAFLD风险增加和肝脏内胆固醇症有关.
- 植物性食品的质量至关重要;强调营养丰富的选择是NAFLD预防的建议.
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