假牙的使用和心脏代谢疾病的风险:观察和孟德尔随机化分析
Yunan Liu1, Haiqiang Qin2, Tongtong Li1
1CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai 200031, China.
European journal of preventive cardiology
|September 12, 2023
概括
假牙使用可能会增加心力衰竭,中风和2型糖尿病的风险. 这项研究探讨了假牙使用的遗传责任和心脏代谢疾病之间的潜在因果关系.
科学领域:
- 心血管科学 心血管科学
- 遗传学 是一个遗传学.
- 公共卫生 公共卫生
背景情况:
- 假牙使用与心脏代谢疾病 (CMD) 的潜在联系尚不清楚.
- 调查因果关系对于公共卫生战略至关重要.
研究的目的:
- 调查假牙使用的遗传责任与CMD之间的潜在因果关系和关联的强度.
- 探索CMD和相关风险因素的遗传相关性和门德尔随机化分析.
主要方法:
- 利用了来自495,938名参与者的英国生物库数据.
- 雇佣的链接不平衡得分 (LDSC) 回归和门德尔随机化分析.
- 牙腐烂时使用假牙的综合遗传数据 (DMFS) 进行全面分析.
主要成果:
- 观察分析显示,假牙使用的CMD风险增加了14-25%.
- 据LDSC发现,假牙使用与CMD之间存在积极的遗传相关性 (rg 0.21-0.38).
- 假牙使用的遗传责任与心力衰竭 (HF) 和2型糖尿病 (T2D) 的风险增加有关.
- 遗传预测的假牙使用/DMFS与任何中风 (AS) 的风险增加以及心脏代谢风险因素的改变 (HDL,甘油三,腰围等) 相关. ) 的情况.
结论:
- 这些发现支持了假牙使用的遗传责任与HF,AS,T2D的风险之间的潜在因果关系.
- 结果强调了在预防CMD方面关注牙健康的重要性.
- 为牙科疾病和CMD的综合预防和干预策略提供信息.
相关概念视频
Study Designs in Epidemiology
263
Epidemiological study designs are fundamental tools for investigating the distribution, determinants, and control of health conditions in populations. They help researchers understand the relationships between exposures and outcomes, and they broadly fall into two categories: "observational" and "experimental" studies.
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
263
Observational Studies
8.7K
Observational studies are a type of analytical study where researchers observe events without any interventions. In other words, the researcher does not influence the response variable or the experiment's outcome.
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
There are three types of observational studies – Prospective, retrospective, and cross-sectional.
Prospective Study
Prospective studies, also known as longitudinal or cohort studies, are carried out by collecting future data from groups sharing similar characteristics. One...
8.7K
Coronary Artery Disease I: Introduction
20
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
20
Teeth
482
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
482
Longitudinal Studies
186
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
186
Mechanistic Models: Compartment Models in Individual and Population Analysis
64
Mechanistic models are utilized in individual analysis using single-source data, but imperfections arise due to data collection errors, preventing perfect prediction of observed data. The mathematical equation involves known values (Xi), observed concentrations (Ci), measurement errors (εi), model parameters (ϕj), and the related function (ƒi) for i number of values. Different least-squares metrics quantify differences between predicted and observed values. The ordinary least...
64


