偶然性与症状性非功能性垂体腺瘤:它们有什么不同?
Vanessa Guerreiro1,2,3, Fernando Mendonça1,2,3, Helena Urbano Ferreira1,2,3
1Department of Endocrinology, Diabetes and Metabolism, Centro Hospitalar São João, EPE, Porto, Portugal.
Endocrinology, diabetes & metabolism
|September 12, 2023
概括
非功能性垂体腺瘤 (NFPA) 经常被偶然发现,通常呈现为较大的瘤,伴有较少的相关症状,如垂体缺陷症. 提高意识可能会导致这些细胞区域瘤的早期检测.
科学领域:
- 神经内分泌学神经内分泌学
- 神经外科 神经外科
- 在瘤学瘤学.
背景情况:
- 非功能性垂体腺瘤 (NFPA) 是常见的细胞区域瘤.
- 由于压缩症状或偶然通过脑成像,NFPA通常被诊断为NFPA.
研究的目的:
- 在十年内确定偶然NFPA诊断的流行率.
- 在偶然和症状诊断的NFPA之间比较临床,分析和治疗差异.
- 评估偶然和症状诊断的NFPA之间的病理差异.
主要方法:
- 对18岁或以上明显NFPA患者的回顾性分析.
- 纳入标准包括基于病变大小的特定益生素水平值.
- 患者被分为偶发性或症状性诊断组.
主要成果:
- 在119名患者中,47.1%的NFPA被偶然诊断为NFPA.
- 偶发性NFPA与症状性NFPA相比,较少发生hypopituitarism (41.1%) 的情况 (66.7%).
- 偶然的NFPA更常见于宏腺瘤 (87.4%) 和较少接受手术 (50%),而不是症状病例 (75.8%).
结论:
- NFPA通常是偶然诊断的,许多人表现出微妙的症状.
- 偶然诊断的NFPA通常是宏腺瘤,不太可能与hypopituitarism有关.
- 增强的临床怀疑和知识可以促进NFPA的早期检测.
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