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The first successfully cloned mammal was Dolly, a sheep, born on 5th July 1996 at Roslin Institute, Scotland. The cloned sheep was named after the American singer Dolly Parton. Dolly lived for seven years and died of respiratory complications, which is speculated to be due to the actual age of her DNA. Because the DNA in cloned cells belongs to an older individual,  the cloned individual’s life expectancy may be affected. Indeed, analysis of Dolly’s DNA revealed shorter...
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Behavioral imprinting is observed in some newborn animals and occurs when they develop strong and specific attachments to another animal (usually a parent) following brief, early-life exposures. Offspring imprint onto parents within a brief period after birth or hatching; this time window is called the critical period. Once imprinting occurs, the bond established between the parents and their offspring is usually long-lasting.
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相关实验视频

Updated: Jul 16, 2025

Instrumentation of Near-term Fetal Sheep for Multivariate Chronic Non-anesthetized Recordings
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发展规划:怀孕期间的压力会改变绵羊的后代发育.

Mingji Wei1,2, Qian Gao2, Junjun Liu3

  • 1College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, China.

Reproduction in domestic animals = Zuchthygiene
|September 12, 2023
PubMed
概括

羊的产前孕产妇压力 (PMS) 对后代的发育产生负面影响,影响出生体重,行为和大脑结构. 这些影响可以持续到成年和后代.

关键词:
产前母亲的压力 产前母亲的压力编程效应的影响.绵羊的表型 绵羊的表型

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科学领域:

  • 生殖生物学 生殖生物学
  • 发育神经科学的发展神经科学.
  • 动物行为 动物行为

背景情况:

  • 怀孕期间母亲的压力可以引起后代的持久变化.
  • 不适当的动物管理做法是产前压力的来源.
  • 产前母亲压力 (PMS) 编程效应可以影响多代人.

研究的目的:

  • 系统地审查PMS对绵羊后代表型的影响.
  • 为了确定PMS和后代编程之间的调解者.
  • 总结PMS各种实验范式的发现.

主要方法:

  • 对使用人工增加母体葡萄糖皮质激素水平的研究进行系统审查.
  • 对使用在羊群中产前生理压力范式的研究进行分析.
  • 检查与PMS相关的媒介和后代表型.

主要成果:

  • 孕前综合征会损害后代的出生体重,并改变下丘脑-垂体-上腺轴的发育.
  • 产前压力会改变后代的行为,认知能力,基因表达和大脑形态.
  • 观察到的效应可以延伸到成年期并影响后代.

结论:

  • 产前母亲的压力显著影响羊的后代发育和编程.
  • 需要进一步研究基因表达,免疫功能,肠道微生物组和性别特异性影响.
  • 研究治疗策略以扭转有害的编程影响至关重要.