发展规划:怀孕期间的压力会改变绵羊的后代发育
Mingji Wei1,2, Qian Gao2, Junjun Liu3
1College of Bioscience and Biotechnology, Yangzhou University, Yangzhou, China.
Reproduction in domestic animals = Zuchthygiene
|September 12, 2023
概括
羊的产前孕产妇压力 (PMS) 对后代的发育产生负面影响,影响出生体重,行为和大脑结构. 这些影响可以持续到成年和后代.
科学领域:
- 生殖生物学 生殖生物学
- 发育神经科学的发展神经科学.
- 动物行为 动物行为
背景情况:
- 怀孕期间母亲的压力可以引起后代的持久变化.
- 不适当的动物管理做法是产前压力的来源.
- 产前母亲压力 (PMS) 编程效应可以影响多代人.
研究的目的:
- 系统地审查PMS对绵羊后代表型的影响.
- 为了确定PMS和后代编程之间的调解者.
- 总结PMS各种实验范式的发现.
主要方法:
- 对使用人工增加母体葡萄糖皮质激素水平的研究进行系统审查.
- 对使用在羊群中产前生理压力范式的研究进行分析.
- 检查与PMS相关的媒介和后代表型.
主要成果:
- 孕前综合征会损害后代的出生体重,并改变下丘脑-垂体-上腺轴的发育.
- 产前压力会改变后代的行为,认知能力,基因表达和大脑形态.
- 观察到的效应可以延伸到成年期并影响后代.
结论:
- 产前母亲的压力显著影响羊的后代发育和编程.
- 需要进一步研究基因表达,免疫功能,肠道微生物组和性别特异性影响.
- 研究治疗策略以扭转有害的编程影响至关重要.
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