为芯片上的仿生器官量身定制生物材料
Lingyu Sun1, Feika Bian1, Dongyu Xu1
1Department of Rheumatology and Immunology, Nanjing Drum Tower Hospital, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China. yjzhao@seu.edu.cn.
Materials horizons
|September 12, 2023
概括
生物材料对于开发先进的芯片器官至关重要,微流体设备模仿人类器官功能. 本次审查强调了它们在创建更好的药物测试模型和了解疾病方面的作用.
科学领域:
- 生物材料科学 生物材料科学
- 组织工程是组织工程.
- 微流体学 微流体学
背景情况:
- 芯片上的器官是复制器官功能的微流体设备.
- 他们提供先进的细胞培养,模仿体内环境.
- 生物材料对于器官在芯片上的微观结构和功能至关重要.
研究的目的:
- 为提供用于芯片器官的生物材料的概述.
- 讨论生物材料的功能,制造和应用.
- 突出器官芯片作为动物试验的替代品的潜力.
主要方法:
- 对芯片器官生物材料的当前文献的综述.
- 生物材料组件,结构和制造技术的分析.
- 研究生物材料在芯片器官系统中的功能和应用.
主要成果:
- 生物材料显著影响器官芯片上的器官的性能.
- 使用各种生物材料,影响细胞行为和设备功能.
- 基于生物材料的器官芯片显示出有希望的动物模型替代品.
结论:
- 生物材料对于推进器官芯片技术至关重要.
- 对生物材料的进一步研究将提高器官在芯片上的能力.
- 这些先进的模型对制药,化学和环境测试有重大影响.
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