替代拼接的调节:与表观遗传修饰的功能相互作用及其对癌症的影响
Ning Wang1,2, Yue Hu1,2, Zefeng Wang1,2
1Bio-Med Big Data Center, CAS Key Laboratory of Computational Biology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Nutrition and Health, Shanghai, China.
Wiley interdisciplinary reviews. RNA
|September 12, 2023
概括
本综述探讨了表观遗传修饰如何调节替代拼接,这是真核生物基因表达的一个关键过程. 了解这种相互作用可以导致治疗与拼接失调相关的癌症等疾病的新策略.
科学领域:
- 分子生物学分子生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 在RNA生物学,RNA生物学.
背景情况:
- 细胞基因表达涉及复杂的调节,包括mRNA前处理和替代拼接.
- 替代拼接从单个基因中产生多样化的mRNA异型,增加了基因组的复杂性.
- 基因表达调节层,包括拼接,往往在功能上相互作用,特别是在共同转录过程中.
研究的目的:
- 审查三层的替代拼接法规:拼接机械,转录和染色质结构.
- 强调表观遗传修饰的调节作用及其与拼接的交叉声.
- 讨论表观遗传变化对癌症拼接失调的影响.
主要方法:
- 审查关于表观遗传修饰和替代拼接的现有文献.
- 对剪接的表观遗传影响分为三种类型:转录率,剪接因子招募和剪接因子表达/活性.
- 讨论将表观遗传变化与拼接失调和功能后果联系在一起的机制.
主要成果:
- 表观遗传修饰通过改变转录速率,招募拼接因子或影响拼接因子表达/活性来影响替代拼接.
- 在表观遗传调节,转录和拼接机械之间存在交叉声.
- 表观遗传学和拼接的失调在癌症中很普遍,已确定了特定的机制.
结论:
- 表观遗传修饰在调节替代拼接方面发挥着至关重要的作用.
- 了解表观遗传学和拼接之间的相互作用为新的治疗策略提供了潜力.
- 针对表观遗传和拼接失调可能为疾病治疗提供新的途径,特别是在癌症中.
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