持续分配:EPTS和儿科候选人的问题
Rachel M Engen1, Samantha Weiss2, Caitlin G Peterson3
1Department of Pediatrics, University of Wisconsin Madison, Madison, Wisconsin, USA.
Pediatric transplantation
|September 12, 2023
概括
在成年人脏移植中使用的移植后预估存活 (EPTS) 评分被评估为儿科患者. 该研究发现,EPTS不是接受移植的儿童患者生存的有效预测指标.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 移植 移植 移植 移植
- 儿科医学 儿科医学
背景情况:
- 2014年分配系统 (KAS) 使用成年移植候选人的预估移植后生存 (EPTS) 评分.
- EPTS考虑了年龄,透析持续时间,糖尿病和之前的移植来预测移植的寿命.
- 对于儿科移植接受者的EPTS适用性尚不清楚.
研究的目的:
- 评估EPTS得分在预测儿科移植患者患者存活率方面的有效性.
- 评估专为成人设计的EPTS评分是否在儿科患者群体中表现准确.
主要方法:
- 在6800名儿科移植接受者的回顾性队列研究 (2001-2011).
- 数据来源于器官采购和移植网络 (OPTN).
- 计算了EPTS得分,并将其与患者实际生存结果进行了比较.
主要成果:
- 患者的平均年龄为14.01岁;透析年龄的平均年龄为0.67岁.
- 平均EPTS得分为2;7%的患者在研究期间死亡.
- 对于EPTS预测准确度的c统计值为0.505,表明表现不佳.
结论:
- 移植后估计生存率 (EPTS) 评分不是儿童移植患者患者生存率的有效预测指标.
- 目前的EPTS评分系统需要重新评估,以便在儿科患者群体中使用.
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