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检查长期COVID患者对I型干扰素的自身抗体

Kristoffer Skaalum Hansen^1,2, Sofie Eg Jørgensen^1,3, Morten Kelder Skouboe^1,3

¹Department of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.

Journal of medical virology

|September 12, 2023

概括

对长期COVID (LC) 患者的1型干扰素 (IFN) 的自身抗体进行了研究. 这项研究发现,在LC患者和对照者之间,抗I型IFN自身抗体患病率没有显著差异,这表明它们不会导致LC症状.

科学领域:

免疫学免疫学免疫学
传染性疾病传染性疾病
这是一种自身免疫力.

背景情况:

长期COVID (LC) 是一个重大的全球健康挑战,其潜在机制尚不清楚.
对1型干扰素 (IFN) 的自身抗体是已知的COVID-19严重程度的预测因素.
持续的自身免疫活性,特别是抗I型IFN自身抗体,被假定有助于LC症状.

研究的目的:

在丹麦长期COVID队列中调查1型干扰素 (IFN) 自身抗体的患病率.
为了确定与抗I型IFN自身抗体持续的自身免疫活性是否有助于长期COVID症状.

主要方法:

血样本和临床数据来自279名成年长期COVID患者和94名具有先前轻度SARS-CoV-2感染的对照组.
使用酶相关免疫吸收试验 (ELISA) 检测出1型IFN自身抗体.
使用特定问卷评估了症状数据和生活质量.

主要成果:

在1.8%的长期COVID患者和3.2%的对照人群中发现了可检测的循环型1型IFN自身抗体.
在LC队列中,抗I型IFN自身抗体的患病率并不超过对照组.
流行率主要在LC队列中的男性中观察到.

结论:

在这个队列中,针对1型干扰素的自身抗体不太可能成为长期COVID症状的主要驱动因素.
需要进一步的研究来阐明长期COVID的复杂病理生理学.

关键词:

这是自抗体的自抗体.自体免疫性是一种自身免疫性.免疫学免疫学免疫学干扰子干扰子干扰子长时间的COVID.

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