孕期糖尿病之后的孕妇糖尿病:多胎妊娠是否会增加风险?
Tamar Wainstock1, Israel Yoles2, Ruslan Sergienko1
1Department of Public Health, Faculty of Health Science, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
概括
在双胞胎怀孕期间被诊断患有妊娠期糖尿病 (GD) 的女性,与单独怀孕的女性相比,未来患糖尿病的风险较低. 这一发现即使考虑了各种风险因素后也是如此.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 糖尿病研究 糖尿病研究
背景情况:
- 孕期糖尿病 (GD) 是母亲未来2型糖尿病的重要危险因素.
- 了解基于妊娠类型的GD的长期影响对于风险分层和管理至关重要.
研究的目的:
- 为了比较在双胞胎怀孕和单独怀孕期间被诊断患有GD的女性未来糖尿病发病风险.
- 根据多次怀孕来确定糖尿病发病率的潜在差异.
主要方法:
- 在1991年至2021年期间,对至少有一次GD诊断的妇女进行了回顾性队列研究.
- 双胞胎与单子妊娠中GD诊断的比较,随访时间长达30年.
- 第一次产后和最高随访血红蛋白A1C (HbA1C) 水平的分析,使用多变量后勤和Cox比例分析.
主要成果:
- 包括13,770名母亲;3.3%在双胞胎怀孕期间患有GD,96.7%在单独怀孕期间.
- 双胞胎怀孕组的糖尿病发病率较低 (15.5%与22.1%分娩后;31.8%与40.7%长期).
- 经过调整年龄,种族和生育治疗后,结果仍然显著.
结论:
- 在多次怀孕期间诊断出妊娠糖尿病与未来糖尿病风险降低有关.
- 在双胞胎怀孕期间患有GD的女性,产后和长期糖尿病的发病率较低.
- 这表明,在多胎妊娠中,GD后的代谢轨迹可能不同.
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