一个前性的,多中心的,关于手术与非手术治疗下垂体中风的观察性研究
Adam N Mamelak1, Andrew S Little2, Paul A Gardner3
1Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
The Journal of clinical endocrinology and metabolism
|September 12, 2023
概括
通过手术或医疗治疗治疗下垂体中风 (PA) 的管理在3个月后显示出类似的结果. 手术并不总是必要的,因为瘤体积可以自然减少,改善质量效应.
科学领域:
- 内分泌学 在内分泌学.
- 神经外科 神经外科
- 眼科医生 眼科 眼科
背景情况:
- 下垂体脑梗塞 (PA) 通常被视为神经外科紧急情况.
- 然而,证据表明,手术和医疗管理之间的结果相似.
研究的目的:
- 为了比较PA患者的表现和结果,手术治疗与医疗治疗相比.
- 为PA研究建立一个多中心的国际前性注册表.
主要方法:
- 收集有关人口统计,并发病,临床表现,视觉和荷尔蒙状况以及成像的数据.
- 评估结果包括视觉,眼运动和荷尔蒙恢复,并发症和住院.
- 基于治疗时间和视野缺陷严重程度的结果比较.
主要成果:
- 招募了100名PA患者;97人是可评估的 (67人是外科,30人是医疗).
- 群体之间的人口统计和临床特征相似;手术患者的视野缺陷更严重.
- 两个管理组的荷尔蒙,视觉和眼运动结局在3个月和6个月是相似的.
结论:
- 脑下垂体中风的医疗和手术治疗在3个月后产生了类似的结果.
- 手术可能并不总是必要的,因为自发的瘤回归可以减少质量效应.
- 需要进一步的研究才能确定外科手术的益处.
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