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使用主要组件分析,区分异位性中央早发性青春期与早发性乳头发病

Amanda Cleemann Wang¹, Casper P Hagen^1,2, Trine Holm Johannsen^1,2

¹Department of Growth and Reproduction, Copenhagen University Hospital-Rigshospitalet, DK-2100 Copenhagen, Denmark.

The Journal of clinical endocrinology and metabolism

|September 12, 2023

概括

区分早发性乳头发病 (PT) 与女孩的异常性中央早发性青春期 (ICPP) 是非常重要的. 使用主要成分分析 (PCA) 分析的临床和激素资料的组合显著提高了诊断准确度,而不是单个标记.

科学领域:

儿科内分泌学儿科内分泌学
生殖健康生殖健康
临床诊断临床诊断临床诊断

背景情况:

过早的乳头发 (PT) 是一种良性,自我限制的疾病,而异常性中央早熟性青春期 (ICPP) 是一种需要医疗干预的疾病.
将PT与ICPP区分开来是具有挑战性的,因为它们的初始表现相似,主要是乳房的孤立发育.

研究的目的:

分析早期青春期的大量女孩的临床变量.
确定临床和生化标志物,以区分ICPP和PT.

主要方法:

对1361名女孩进行回顾性分析,指出了早期青春期的迹象 (2009-2019).
评估临床表现,病史,生长速度,骨龄,激素水平和GnRH测试结果.
接收器运行特征 (ROC) 分析和主要组件分析 (PCA) 的应用.

主要成果:

在被推的女孩中,ICPP被诊断为11%,PT为8%.
没有一个单一的生化或人体测量标志物能够充分区分ICPP和PT.
在区分ICPP与PT方面,PCA衍生复合型材实现了90%的特异性和84%的灵敏性,优于单个标记.

结论:

个别的临床和生化参数为区分ICPP和PT提供了一些支持.
通过PCA减少临床和荷尔蒙特征的尺寸,提高了诊断价值.
基于PCA的个人资料可以作为GnRH检测青春期疾病的宝贵补充.

关键词:

诊断差异化诊断差异化过早的青春期过早的青春期过早发生的larche.主要组件分析的主要组件分析青春期的青春期,就是青春期.

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