胰岛素样生长因子结合蛋白-2作为狼性炎生物标志物
Phuong Thi Luong1,2, Thuy Thi Dieu Nguyen1,2, Ngoc Thi Nguyen2
1Hanoi Medical University, Hanoi, Vietnam.
Pediatrics international : official journal of the Japan Pediatric Society
|September 12, 2023
概括
血清胰岛素样生长因子结合蛋白-2 (IGFBP-2) 是儿科狼性炎 (LN) 的一个有前途的非侵入性生物标志物. 患有LN儿童的IGFBP-2水平升高反映了疾病活性和病理,有助于诊断和监测.
科学领域:
- 儿科脏病学 儿科脏病学
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 狼性炎 (LN) 是系统性红斑狼 (SLE) 的严重并发症.
- 准确的非侵入性生物标志物是必要的,用于早期诊断和管理儿科LN.
- 目前的诊断方法可能是侵入性的,可能无法完全捕捉疾病的活性.
研究的目的:
- 研究血清胰岛素样生长因子结合蛋白-2 (IGFBP-2) 作为儿科LN的新型非侵入性生物标志物.
- 评估IGFBP-2水平与临床疾病活性和LN儿童病理的相关性.
主要方法:
- 一项横截面研究包括93名新诊断的活检证明的儿科LN患者,35名没有脏参与的SLE儿童和30名健康对照.
- 使用ELISA测量血清IGFBP-2水平.
- 收集和分析了临床,实验室和组织病理学数据.
主要成果:
- 与SLE患者和健康对照人群相比,儿科LN患者的血清IGFBP-2水平显著更高.
- IGFBP-2在区分LN与SLE和健康对照中表现出高的诊断准确性 (AUC>0.89).
- 与疾病活性相关的IGFBP-2水平 (SLEDAI),低蛋白,蛋白尿,GFR降低,以及重要的是,活动指数.
结论:
- 血清IGFBP-2是一种有前途的非侵入性生物标志物,用于儿科狼性炎.
- IGFBP-2水平反映了儿科LN患者的临床疾病活性和病理严重程度.
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