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铜 (II) 催化级联Csp2-P/C-C键形成以构建二基酸盐

Han Wang¹, Le Huang¹, Jun Li¹

¹College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, People's Republic of China. wenyanhao@jxnu.edu.cn.

Organic & biomolecular chemistry

|September 12, 2023

概括

一个新的铜催化反应有效地合成了使用有机 Ester 和o-haloaryl isothiocyanate 的[d]thiazol-2-ylphosphonates. 这种温和的离子通路对合成这些重要化合物的传统激素方法具有优势.

科学领域:

有机化学有机化学
催化剂是一种催化剂.
合成方法论合成方法论

背景情况:

[d]thiazol-2-ylphosphonates是药物化学中的有价值的支架.
传统合成通常依赖于激进反应,这些反应可能是苛刻的,效率较低的.
开发更温和,更容易获得的合成路径对于更广泛的应用至关重要.

研究的目的:

开发一种新的铜 (II) 催化级联反应,用于形成C-P和C-C键.
在温和的条件下合成[d]醇-2-ylphosphonates.
建立一个高效和可扩展的方法来访问这些化合物.

主要方法:

使用的铜 (II) 催化剂用于级联反应.
作为原料使用的o-haloaryl isothiocyanates和有机质.
为了获得最佳产量和选择性,研究了反应条件.

主要成果:

成功合成了一系列的[d]thiazol-2-ylphosphonates. 已经成功合成了一系列的[d]thiazol-2-ylphosphonates.
对目标化合物实现了中等到良好的产量.
通过格拉姆尺度合成证明了该方法的可扩展性.

结论:

开发了一种新的,温和而高效的铜催化级联反应.
拟议的离子反应途径比传统的激素方法具有优势.
该策略具有可扩展性,可以轻松获取有价值的[d]-2-基酸盐.

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