相关实验视频
Updated: Jul 16, 2025

07:37
An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
Published on: June 6, 2025
188
表观遗传衰老和类风湿性关节炎
Nandini Mukherjee1, Tracie C Harrison2
1Department of Epidemiology, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
概括
这项研究发现,先进的表观遗传年龄,特别是使用像GrimAge这样的第二代时钟,与类风湿性关节炎 (RA) 患病率有关. 与对照组相比,在RA病例中观察到更高的表观遗传年龄加速.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 类风湿病学 类风湿病学
- 衰老研究研究 衰老研究
背景情况:
- 类风湿性关节炎 (RA) 是一种具有复杂病因的慢性自身免疫性疾病.
- 表观遗传年龄估计提供了对生物衰老的分子测量.
- 以前的研究还没有比较评估各种表观遗传年龄指标与RA患病率.
研究的目的:
- 进行首次对多种表观遗传年龄估计及其与类风湿性关节炎 (RA) 患病率相关性的比较评估.
- 调查不同表观遗传钟的实用性,包括第一和第二代测量,作为RA的潜在生物标志物.
主要方法:
- 使用了来自瑞典风湿关节炎流行病学调查研究 (GSE42861) 的DNA甲基化 (DNAm) 数据.
- 计算了多个表观遗传年龄估计:DNAmTL,Hannum,Horvath 2013,Horvath 2018,PhenoAge和GrimAge,以及它们的加速量.
- 使用线性回归,调整性别和吸烟,对多次测试进行FDR校正,评估了与RA患病率的关联.
主要成果:
- 在RA患病率和几种表观遗传衰老加速措施之间发现了统计学上显著的关联,特别是PhenOAge加速和GrimAge加速.
- 与健康对照组相比,在RA病例中观察到更高的表观遗传年龄加速.
- GrimAge及其加速与RA有很强的关联,在RA病例中,GrimAge替代DNAm蛋白成分较高.
结论:
- 第二代表观遗传时钟,特别是PhenoAge和GrimAge,在类风湿性关节炎的背景下显示出生物衰老的标志物.
- 表观遗传年龄加速是与RA患病率相关的潜在指标.
- 需要进一步的研究来探索这些表观遗传标记在RA中的临床实用性.
相关概念视频
Genome-wide Association Studies-GWAS
13.6K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
13.6K
The Effect of Aging on Tissues
2.1K
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
2.1K
Aging
86
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
86
The JAK-STAT Signaling Pathway
9.0K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as SH2...
9.0K
Epigenetic Regulation
3.1K
Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
X-chromosome...
3.1K
Rheumatic Heart Disease I: Introduction
16
Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
16

