在最初诊断时,头癌与远程转移的治疗结果
Jo Omata1, Yushi Ueki1, Yuto Takahashi1
1Department of Otolaryngology Head and Neck Surgery, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
The Laryngoscope
|September 12, 2023
概括
结合免疫检查点抑制剂 (ICI) 与放射治疗 (RT) 或手术的强化治疗改善了诊断时患有远程转移的头部和部状细胞癌 (HNSCC) 患者的生存率.
科学领域:
- 在瘤学瘤学.
- 头部和部癌症研究研究
背景情况:
- 复发性/转移性头角状细胞癌 (HNSCC) 治疗已经通过免疫检查点抑制剂 (ICI) 进化.
- 在初始诊断时存在远程转移 (M1) 的HNSCC数据有限,缺乏标准化的治疗策略.
研究的目的:
- 分析治疗结果,并确定诊断初始M1疾病的HNSCC患者的预后因素.
主要方法:
- 一项多机构追溯研究,对98名初始M1疾病的HNSCC患者进行了多机构追溯研究 (2007-2021).
- 患者被分为非息性 (全身化疗,n=60) 和息性 (没有化疗,n=38) 组.
- 总体生存率 (OS) 进行了比较,在非息治疗组中探索了OS的预测因素.
主要成果:
- 与息治疗组 (3个月) 相比,非息治疗组 (15个月) 的中位 OS 显著更长 (p < 0.001).
- 改善OS的独立预后因素包括局部区域辐射疗法 (RT) (HR 0.407),ICI (HR 0.216) 和远程转移的RT/手术 (HR 0.373).
结论:
- 综合系统治疗与ICI和RT/手术用于局部或远程转移的密集治疗策略可以改善初始M1疾病的HNSCC患者的生存率.
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