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在印度发现的 Staphylococcus aureus 克隆复合体22 的新型多药耐药亚系

Monica I Abrudan^1,2, Varun Shamanna^3,4, Akshatha Prasanna³

¹Centre for Genomic Pathogen Surveillance, Big Data Institute, University of Oxford , Oxford, United Kingdom.

|September 12, 2023

概括

整个基因组测序揭示了印度的新型甲素耐药黄金葡萄球菌 (MRSA) 血统,与全球菌株不同. 这项研究提高了对MRSA流行病学和耐药性的理解,这对公共卫生至关重要.

科学领域:

微生物学与传染病的研究
基因组学和分子流行病学
公共卫生和流行病学

背景情况:

金黄色葡萄球菌 (Staphylococcus aureus) 是印度的一个重要病原体,导致社区和医院感染.
关于印度医院环境中S. aureus分子流行病学和耐药机制的数据有限.
甲素耐药黄金葡萄球菌 (MRSA) 构成了日益严重的全球健康挑战.

研究的目的:

用全基因组测序 (WGS) 来描述印度S. aureus临床分离物的分子流行病学.
识别新的MRSA血统,了解它们的抵抗机制和进化历史.
为了解印度MRSA的种群结构及其全球背景提供见解.

主要方法:

从17个印度地点 (2014-2019) 收集的478个S. aureus临床分离物 (393个MRSA,85个MSSA) 的全基因组测序 (WGS).
对克隆复合体 (CC) 22个分离物的深入分析,包括对全球分离物的时间分析.
识别和描述新型ST22MRSA血统和新兴的血统,如ST2371.

主要成果:

序列类型22 (ST22),239 (ST239) 和772 (ST772) 是印度最常见的克隆.
确定了两种新的ST22MRSA基因系,两种都是Panton-Valentine leucocidin阳性,对诺基诺和氨基甘油有抗性;一个携带有毒性休克综合征毒素1 (tst) 基因.
发现了印度ST22血统在全球传播的证据,在1984年发现了一个共同的祖先. ST2371成为一个新的血统. 在班加罗尔发现了一个长达3年的MDR ST239疫情.

结论:

这项WGS研究提供了印度CC22MRSA的第一个全面表征,揭示了不同的印度克隆.
发现了新的,耐药的ST22MRSA血统突出了潜在的治疗挑战和全球公共卫生威胁.
调查结果强调需要进行例行监测和感染控制措施,以减轻医院环境中的MRSA疫情.

关键词:

印度印度印度 ST22 ST22 ST22 ST22 ST22 ST22 ST22 ST22 ST22 ST22 ST22 ST22 ST22 ST22 ST22 ST22 ST22 ST239 一个人的生活.ST772 我们的世界黄金葡萄球菌黄金葡萄球菌在WGS中,使用的是WGS.疫情爆发的原因是

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